| Glossary Term | Recombinant Inbred Strain |
| Definition |
In mouse and other species, an inbred strain started from an intercross of two or more strains (usually themselves fully inbred) followed by inbreeding for at least 20 to 30 generations. Examples include the BXD family (an intercross of C57BL/6J and DBA/2J parental strains) and the Collaborative Cross family (an intercross of eight inbred parental strains). Once genotyped or sequenced, a family of recombinant inbred strains can be used to establish linkage between heritable differences in phenotypes and polymorphic DNA markers. RI families can also be used in reverse genetic studies to evaluate the pleiotropic effects of segregating variants on many phenotypes. RI strains are particularly advantageous in building up large phenomes, for analysis of gene-by-environmental interactions, and for boosting effective trait heritability by resampling phenotypes for multiple members of each constituent family member. See also the Rules for Nomenclature of Mouse and Rat Strains. |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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