Go Annotations as Summary Text (Tabular View) (GO Graph)

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Automated description from the Alliance of Genome Resources (Release 7.4.0)

Enables dystroglycan binding activity and laminin binding activity. Involved in several processes, including nervous system development; regulation of neurotransmitter receptor localization to postsynaptic specialization membrane; and retrograde trans-synaptic signaling by trans-synaptic protein complex. Acts upstream of or within several processes, including basement membrane organization; commissural neuron axon guidance; and morphogenesis of an epithelium. Located in several cellular components, including external side of plasma membrane; node of Ranvier; and sarcolemma. Part of dystroglycan complex. Is active in several cellular components, including GABA-ergic synapse; cell surface; and photoreceptor ribbon synapse. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; musculature; and sensory organ. Used to study autosomal recessive limb-girdle muscular dystrophy type 2P; dilated cardiomyopathy; and lissencephaly. Human ortholog(s) of this gene implicated in bronchopulmonary dysplasia; inclusion body myositis; and muscular dystrophy (multiple). Orthologous to human DAG1 (dystroglycan 1).

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Gene Ontology Evidence Code Abbreviations:

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