Automated description from the Alliance of Genome Resources (Release 7.2.0)
Enables cytokine activity and frizzled binding activity. Involved in Norrin signaling pathway; extracellular matrix-cell signaling; and positive regulation of DNA-templated transcription. Acts upstream of or within several processes, including camera-type eye development; cell surface receptor signaling pathway; and nervous system development. Located in collagen-containing extracellular matrix. Is expressed in several structures, including brain and sensory organ. Used to study Norrie disease and exudative vitreoretinopathy. Human ortholog(s) of this gene implicated in Norrie disease; X-linked exudative vitreoretinopathy 2; and retinopathy of prematurity. Orthologous to human NDP (norrin cystine knot growth factor NDP).
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