Go Annotations as Summary Text (Tabular View) (GO Graph)

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Automated description from the Alliance of Genome Resources (Release 7.4.0)

Enables cyclin binding activity and cyclin-dependent protein serine/threonine kinase inhibitor activity. Involved in several processes, including cellular response to UV-B; cellular response to amino acid starvation; and negative regulation of cardiac muscle tissue regeneration. Acts upstream of or within several processes, including cellular response to gamma radiation; negative regulation of macromolecule metabolic process; and signal transduction by p53 class mediator. Located in cytosol and nucleus. Part of cyclin-dependent protein kinase holoenzyme complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and sensory organ. Used to study hepatocellular carcinoma; systemic lupus erythematosus; and urinary bladder cancer. Human ortholog(s) of this gene implicated in high grade glioma; ocular hypertension; oral mucosa leukoplakia; oral squamous cell carcinoma; and primary open angle glaucoma. Orthologous to human CDKN1A (cyclin dependent kinase inhibitor 1A).

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Gene Ontology Evidence Code Abbreviations:

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