Automated description from the Alliance of Genome Resources (Release 7.4.0)
Enables signaling adaptor activity. Involved in several processes, including positive regulation of Rac protein signal transduction; positive regulation of skeletal muscle acetylcholine-gated channel clustering; and postsynaptic specialization assembly. Acts upstream of or within several processes, including cell surface receptor signaling pathway; circulatory system development; and nervous system development. Located in synapse. Part of protein-containing complex. Is active in neuromuscular junction. Is extrinsic component of postsynaptic membrane. Is expressed in several structures, including branchial arch; central nervous system; genitourinary system; immune system; and musculature. Used to study DiGeorge syndrome and velocardiofacial syndrome. Human ortholog(s) of this gene implicated in chronic myeloid leukemia. Orthologous to human CRKL (CRK like proto-oncogene, adaptor protein).
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