Go Annotations as Summary Text (Tabular View) (GO Graph)

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Automated description from the Alliance of Genome Resources (Release 7.4.0)

Enables protease binding activity; receptor ligand activity; and tumor necrosis factor receptor binding activity. Involved in several processes, including cellular response to cytokine stimulus; macrophage activation; and positive regulation of cell communication. Acts upstream of or within several processes, including apoptotic signaling pathway; regulation of gene expression; and response to bacterium. Located in several cellular components, including external side of plasma membrane; phagocytic cup; and recycling endosome. Is active in extracellular space. Is expressed in several structures, including brain; genitourinary system; gut; integumental system; and lung. Used to study several diseases, including autoimmune disease (multiple); congestive heart failure; heart valve disease (multiple); idiopathic pulmonary fibrosis; and spondyloarthropathy. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); eye disease (multiple); lung disease (multiple); and skin disease (multiple). Orthologous to human TNF (tumor necrosis factor).

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Gene Ontology Evidence Code Abbreviations:

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