Automated description from the Alliance of Genome Resources (Release 7.4.0)
Predicted to enable metal ion binding activity and serine-type endopeptidase activity. Involved in complement activation. Located in extracellular space. Is expressed in several structures, including endocrine gland; eye; genitourinary system; gut; and liver and biliary system. Used to study glomerulonephritis. Human ortholog(s) of this gene implicated in Kuhnt-Junius degeneration; age related macular degeneration 13; atypical hemolytic-uremic syndrome; complement factor I deficiency; and macular degeneration. Orthologous to human CFI (complement factor I).
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