Automated description from the Alliance of Genome Resources (Release 7.4.0)
Enables identical protein binding activity and rRNA binding activity. Involved in positive regulation of protein localization to nucleolus; positive regulation of transcription by RNA polymerase II; and protein stabilization. Acts upstream of or within several processes, including positive regulation of protein modification process; regulation of gene expression; and ribosome biogenesis. Located in centrosome; cytosol; and nuclear lumen. Part of large ribosomal subunit and small ribosomal subunit. Is expressed in several structures, including early conceptus; neural tube; oocyte; small intestine crypt of lieberkuhn; and telencephalon. Used to study myelodysplastic syndrome. Human ortholog(s) of this gene implicated in acute myeloid leukemia. Orthologous to human NPM1 (nucleophosmin 1).
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