Automated description from the Alliance of Genome Resources (Release 7.4.0)
Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; E-box binding activity; and histone deacetylase binding activity. Involved in several processes, including connective tissue replacement involved in inflammatory response wound healing; negative regulation of ossification; and positive regulation of DNA-templated transcription. Acts upstream of or within several processes, including circulatory system development; epithelial cell differentiation; and negative regulation of apoptotic process. Located in euchromatin; motile cilium; and nuclear speck. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; lung; and sensory organ. Used to study glycogen storage disease V and glycogen storage disease VII. Human ortholog(s) of this gene implicated in carcinoma (multiple); diabetic retinopathy; myocardial infarction; prostate cancer; and type 2 diabetes mellitus. Orthologous to human HIF1A (hypoxia inducible factor 1 subunit alpha).
This site uses cookies.
Some cookies are essential for site operations and others help us analyze use and utility of our web site.
Please refer to our
privacy policy
for more information.