Go Annotations as Summary Text (Tabular View) (GO Graph)

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Automated description from the Alliance of Genome Resources (Release 7.4.0)

Predicted to enable protein homodimerization activity and signaling receptor binding activity. Involved in several processes, including nephron epithelium morphogenesis; nervous system development; and positive regulation of morphogenesis of an epithelium. Acts upstream of or within several processes, including branching involved in ureteric bud morphogenesis; negative regulation of neuron apoptotic process; and organ induction. Predicted to be located in Golgi apparatus and extracellular region. Predicted to be part of receptor complex. Predicted to be active in extracellular space. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and immune system. Used to study Hirschsprung's disease. Human ortholog(s) of this gene implicated in several diseases, including Hirschsprung's disease; Parkinsonism; alcohol dependence; alcohol use disorder; and heroin dependence. Orthologous to human GDNF (glial cell derived neurotrophic factor).

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Gene Ontology Evidence Code Abbreviations:

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