Go Annotations as Summary Text (Tabular View) (GO Graph)

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Automated description from the Alliance of Genome Resources (Release 7.4.0)

Enables ATP-dependent histone chaperone activity; signaling adaptor activity; and signaling receptor binding activity. Involved in several processes, including cellular response to oxidised low-density lipoprotein particle stimulus; positive regulation of macromolecule biosynthetic process; and response to bacterium. Acts upstream of or within several processes, including establishment of endothelial intestinal barrier; regulation of cytokine production; and response to bacterium. Located in cytosol and plasma membrane. Is expressed in several structures, including brain; intestine; and spleen. Used to study Alzheimer's disease; Coronavirus infectious disease; Sjogren's syndrome; and monoclonal gammopathy of uncertain significance. Human ortholog(s) of this gene implicated in colorectal cancer (multiple); hepatocellular carcinoma; lung cancer (multiple); lymphoma (multiple); and primary immunodeficiency disease. Orthologous to human MYD88 (MYD88 innate immune signal transduction adaptor).

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Gene Ontology Evidence Code Abbreviations:

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