Go Annotations as Summary Text (Tabular View) (GO Graph)

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Automated description from the Alliance of Genome Resources (Release 7.4.0)

Enables signaling adaptor activity. Involved in several processes, including hematopoietic or lymphoid organ development; positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation; and regulation of apoptotic process. Acts upstream of or within several processes, including extrinsic apoptotic signaling pathway in absence of ligand; motor neuron apoptotic process; and negative regulation of necroptotic process. Predicted to be located in cell body; cytosol; and plasma membrane. Predicted to be part of CD95 death-inducing signaling complex and ripoptosome. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and liver and biliary system. Human ortholog(s) of this gene implicated in leukemia and primary immunodeficiency disease. Orthologous to human FADD (Fas associated via death domain).

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Gene Ontology Evidence Code Abbreviations:

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