Automated description from the Alliance of Genome Resources (Release 7.2.0)
Enables K48-linked polyubiquitin modification-dependent protein binding activity. Involved in retrograde protein transport, ER to cytosol. Located in cytoplasm. Part of UFD1-NPL4 complex and VCP-NPL4-UFD1 AAA ATPase complex. Is expressed in several structures, including brain; branchial arch; cardiovascular system; forelimb bud; and sensory organ. Human ortholog(s) of this gene implicated in DiGeorge syndrome and schizophrenia. Orthologous to human UFD1 (ubiquitin recognition factor in ER associated degradation 1).
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