Go Annotations as Summary Text (Tabular View) (GO Graph)

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Automated description from the Alliance of Genome Resources (Release 7.4.0)

Enables phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity; protein kinase binding activity; and ubiquitin ligase activator activity. Involved in several processes, including modulation of chemical synaptic transmission; negative regulation of neuron projection development; and nervous system development. Acts upstream of or within several processes, including negative regulation of cell population proliferation; regulation of leukocyte apoptotic process; and regulation of signal transduction. Located in several cellular components, including Schmidt-Lanterman incisure; myelin sheath adaxonal region; and nucleus. Is active in neuron projection. Is expressed in several structures, including alimentary system; central nervous system; egg cylinder; genitourinary system; and sensory organ. Used to study several diseases, including Cowden syndrome (multiple); carcinoma (multiple); macrocephaly-autism syndrome; persistent fetal circulation syndrome; and reproductive organ cancer (multiple). Human ortholog(s) of this gene implicated in several diseases, including PTEN hamartoma tumor syndrome (multiple); breast cancer (multiple); macrocephaly-autism syndrome; nervous system cancer (multiple); and reproductive organ cancer (multiple). Orthologous to human PTEN (phosphatase and tensin homolog).

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Gene Ontology Evidence Code Abbreviations:

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