Gene Ontology Classifications

Symbol
Name
ID

Nck1
non-catalytic region of tyrosine kinase adaptor protein 1
MGI:109601

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Automated description from the Alliance of Genome Resources (Release 7.4.0)

Enables ephrin receptor binding activity; eukaryotic initiation factor eIF2 binding activity; and protein domain specific binding activity. Involved in regulation of gene expression and regulation of response to endoplasmic reticulum stress. Acts upstream of or within several processes, including ephrin receptor signaling pathway; plasma membrane bounded cell projection assembly; and positive regulation of cellular component organization. Located in cell-cell junction and vesicle membrane. Is expressed in several structures, including extraembryonic component; hemolymphoid system gland; male reproductive gland or organ; nervous system; and somite. Orthologous to human NCK1 (NCK adaptor protein 1).

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Aspect

Category

Evidence

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

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Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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