Automated description from the Alliance of Genome Resources (Release 7.4.0)
Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; E-box binding activity; and protein heterodimerization activity. Involved in several processes, including regulation of cell development; regulation of gene expression; and regulation of signal transduction. Acts upstream of or within several processes, including autophagy; protein import into nucleus; and regulation of protein catabolic process. Located in chromatoid body and nuclear body. Part of CLOCK-BMAL transcription complex. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; hemolymphoid system; and retina. Used to study diabetes mellitus. Human ortholog(s) of this gene implicated in alcohol dependence and bipolar disorder. Orthologous to human BMAL1 (basic helix-loop-helix ARNT like 1).
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