Go Annotations as Summary Text (Tabular View) (GO Graph)

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Automated description from the Alliance of Genome Resources (Release 7.4.0)

Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and chromatin binding activity. Involved in several processes, including desmosome disassembly; endocardial cushion formation; and negative regulation of extrinsic apoptotic signaling pathway in absence of ligand. Acts upstream of or within with a positive effect on chromatin organization. Acts upstream of or within several processes, including negative regulation of cell adhesion involved in substrate-bound cell migration; negative regulation of hematopoietic stem cell proliferation; and positive regulation of fat cell differentiation. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and sensory organ. Used to study Waardenburg syndrome. Human ortholog(s) of this gene implicated in piebaldism. Orthologous to human SNAI2 (snail family transcriptional repressor 2).

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Gene Ontology Evidence Code Abbreviations:

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