Go Annotations as Summary Text (Tabular View) (GO Graph)

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Automated description from the Alliance of Genome Resources (Release 7.4.0)

Enables several functions, including ATPase binding activity; identical protein binding activity; and monoatomic cation channel activity. Involved in several processes, including detection of nodal flow; monoatomic cation transmembrane transport; and positive regulation of biosynthetic process. Acts upstream of or within several processes, including intracellular calcium ion homeostasis; liver development; and negative regulation of ryanodine-sensitive calcium-release channel activity. Located in several cellular components, including basal cortex; ciliary membrane; and microtubule cytoskeleton. Part of polycystin complex. Colocalizes with cell-cell junction. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and sensory organ. Used to study autosomal dominant polycystic kidney disease and polycystic kidney disease 2. Human ortholog(s) of this gene implicated in autosomal dominant polycystic kidney disease; intracranial aneurysm; polycystic kidney disease; polycystic kidney disease 2; and retinal degeneration. Orthologous to human PKD2 (polycystin 2, transient receptor potential cation channel).

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Gene Ontology Evidence Code Abbreviations:

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