Automated description from the Alliance of Genome Resources (Release 7.2.0)
Enables identical protein binding activity; receptor ligand activity; and tumor necrosis factor receptor superfamily binding activity. Involved in several processes, including intracellular signaling cassette; positive regulation of canonical NF-kappaB signal transduction; and positive regulation of secretion by cell. Acts upstream of or within several processes, including cellular response to cytokine stimulus; mammary gland development; and positive regulation of intracellular signal transduction. Predicted to be located in cytoplasm; extracellular space; and plasma membrane. Is expressed in bone; genitourinary system; hemolymphoid system; incisor; and rib. Used to study autosomal recessive osteopetrosis 2. Human ortholog(s) of this gene implicated in autosomal recessive osteopetrosis 2 and osteoporosis. Orthologous to human TNFSF11 (TNF superfamily member 11).
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