Automated description from the Alliance of Genome Resources (Release 7.2.0)
Enables DNA-binding transcription activator activity, RNA polymerase II-specific and sequence-specific double-stranded DNA binding activity. Involved in several processes, including nervous system development; positive regulation of cold-induced thermogenesis; and regulation of respiratory gaseous exchange by nervous system process. Acts upstream of or within several processes, including negative regulation of type B pancreatic cell proliferation; nervous system development; and regulation of neuron differentiation. Located in nucleus. Is expressed in several structures, including adrenal gland; epibranchial placode; genitourinary system; gut; and nervous system. Used to study congenital central hypoventilation syndrome. Human ortholog(s) of this gene implicated in colorectal cancer; congenital central hypoventilation syndrome; and neuroblastoma. Orthologous to human PHOX2B (paired like homeobox 2B).
This site uses cookies.
Some cookies are essential for site operations and others help us analyze use and utility of our web site.
Please refer to our
privacy policy
for more information.