Automated description from the Alliance of Genome Resources (Release 7.4.0)
Predicted to enable DNA binding activity; catalytic activity, acting on DNA; and chromatin binding activity. Predicted to be involved in DNA repair; G1/S transition of mitotic cell cycle; and leading strand elongation. Predicted to be located in nucleoplasm and plasma membrane. Predicted to be part of epsilon DNA polymerase complex. Is expressed in nervous system. Human ortholog(s) of this gene implicated in colorectal cancer (multiple); endometrial cancer (multiple); lung cancer (multiple); and mismatch repair cancer syndrome. Orthologous to human POLE (DNA polymerase epsilon, catalytic subunit).
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