Gene Ontology Classifications

Symbol
Name
ID

Birc2
baculoviral IAP repeat-containing 2
MGI:1197009

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Automated description from the Alliance of Genome Resources (Release 7.4.0)

Enables ubiquitin-protein transferase activity. Involved in necroptotic process and positive regulation of canonical NF-kappaB signal transduction. Acts upstream of or within several processes, including cellular response to tumor necrosis factor; negative regulation of necroptotic process; and negative regulation of ripoptosome assembly involved in necroptotic process. Located in cytoplasmic side of plasma membrane. Part of CD40 receptor complex. Is expressed in several structures, including central nervous system; genitourinary system; and thymus primordium. Human ortholog(s) of this gene implicated in breast cancer. Orthologous to human BIRC2 (baculoviral IAP repeat containing 2).

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Aspect

Category

Evidence

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

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Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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