Go Annotations as Summary Text (Tabular View) (GO Graph)

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Automated description from the Alliance of Genome Resources (Release 7.4.0)

Enables cysteine-type endopeptidase activator activity involved in apoptotic process and cysteine-type endopeptidase activity involved in apoptotic process. Involved in several processes, including circulatory system development; negative regulation of necroptotic process; and positive regulation of execution phase of apoptosis. Acts upstream of or within several processes, including activation of cysteine-type endopeptidase activity involved in apoptotic process; hepatocyte apoptotic process; and regulation of apoptotic process. Located in cytoplasm; nucleus; and plasma membrane. Part of Noc1p-Noc2p complex. Is expressed in several structures, including brain; early conceptus; gonad; hemolymphoid system; and limb bud. Used to study atopic dermatitis and autoimmune lymphoproliferative syndrome type 2B. Human ortholog(s) of this gene implicated in several diseases, including autoimmune lymphoproliferative syndrome type 2B; breast cancer; endocrine gland cancer (multiple); esophagus adenocarcinoma; and lung cancer. Orthologous to human CASP8 (caspase 8).

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Gene Ontology Evidence Code Abbreviations:

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