Gene Ontology Classifications

Symbol
Name
ID

Dnmt3a
DNA methyltransferase 3A
MGI:1261827

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Automated description from the Alliance of Genome Resources (Release 7.4.0)

Enables S-adenosylmethionine-dependent methyltransferase activity and nucleic acid binding activity. Involved in autosome genomic imprinting; negative regulation of gene expression via chromosomal CpG island methylation; and retrotransposon silencing by piRNA-directed DNA methylation. Acts upstream of or within several processes, including cellular response to amino acid stimulus; cellular response to bisphenol A; and epigenetic regulation of gene expression. Located in chromosome; cytoplasm; and nucleus. Is expressed in several structures, including brain; early conceptus; genitourinary system; limb mesenchyme; and sensory organ. Human ortholog(s) of this gene implicated in Tatton-Brown-Rahman syndrome; hematologic cancer (multiple); and stomach cancer. Orthologous to human DNMT3A (DNA methyltransferase 3 alpha).

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Aspect

Category

Evidence

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

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Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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