Automated description from the Alliance of Genome Resources (Release 7.2.0)
Enables S-adenosylmethionine-dependent methyltransferase activity; chromatin binding activity; and nucleic acid binding activity. Involved in autosome genomic imprinting and negative regulation of gene expression via chromosomal CpG island methylation. Acts upstream of or within several processes, including cellular response to amino acid stimulus; cellular response to bisphenol A; and regulation of gene expression. Located in chromosome; cytoplasm; and nucleus. Part of heterochromatin. Is expressed in several structures, including brain; early conceptus; genitourinary system; limb mesenchyme; and sensory organ. Human ortholog(s) of this gene implicated in Tatton-Brown-Rahman syndrome; hematologic cancer (multiple); and stomach cancer. Orthologous to human DNMT3A (DNA methyltransferase 3 alpha).
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