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Gene Ontology Classifications
Symbol
Name
ID
Hipk2
homeodomain interacting protein kinase 2
MGI:1314872

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Automated description from the Alliance of Genome Resources (Release 7.4.0)

Enables RNA polymerase II-specific DNA-binding transcription factor binding activity; protein serine/threonine kinase activity; and transcription corepressor activity. Contributes to transcription coactivator activity. Involved in several processes, including camera-type eye morphogenesis; protein phosphorylation; and regulation of DNA-templated transcription. Acts upstream of or within several processes, including adult walking behavior; cell surface receptor signaling pathway; and intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator. Located in cytoplasm and nucleus. Part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including alimentary system; metanephros; nervous system; paraxial mesenchyme; and sensory organ. Orthologous to human HIPK2 (homeodomain interacting protein kinase 2).



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Gene Ontology Evidence Code Abbreviations:

Experimental:
EXP
Inferred from experiment
HMP
Inferred from high throughput mutant phenotype
HGI
Inferred from high throughput genetic interaction
HDA
Inferred from high throughput direct assay
HEP
Inferred from high throughput expression pattern
IDA
Inferred from direct assay
IEP
Inferred from expression pattern
IGI
Inferred from genetic interaction
IMP
Inferred from mutant phenotype
IPI
Inferred from physical interaction
Homology:
IAS
Inferred from ancestral sequence
IBA
Inferred from biological aspect of ancestor
IBD
Inferred from biological aspect of descendant
IKR
Inferred from key residues
IMR
Inferred from missing residues
IRD
Inferred from rapid divergence
ISA
Inferred from sequence alignment
ISM
Inferred from sequence model
ISO
Inferred from sequence orthology
ISS
Inferred from sequence or structural similarity
Automated:
IEA
Inferred from electronic annotation
RCA
Reviewed computational analysis
Other:
IC
Inferred by curator
NAS
Non-traceable author statement
ND
No biological data available
TAS
Traceable author statement

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Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory