Automated description from the Alliance of Genome Resources (Release 7.4.0)
Enables pyruvate dehydrogenase (acetyl-transferring) kinase activity. Involved in several processes, including insulin receptor signaling pathway; regulation of acetyl-CoA biosynthetic process from pyruvate; and regulation of gluconeogenesis. Acts upstream of or within regulation of calcium-mediated signaling. Located in mitochondrion. Part of pyruvate dehydrogenase complex. Is expressed in aorta; cerebral cortex; cerebral cortex subventricular zone; heart; and liver. Orthologous to human PDK2 (pyruvate dehydrogenase kinase 2).
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