Automated description from the Alliance of Genome Resources (Release 7.2.0)
Predicted to enable adenyl-nucleotide exchange factor activity and protein-folding chaperone binding activity. Involved in muscle cell cellular homeostasis. Acts upstream of or within several processes, including cellular response to mechanical stimulus; extrinsic apoptotic signaling pathway in absence of ligand; and protein stabilization. Located in Z disc. Is expressed in several structures, including brain; cardiovascular system; genitourinary system; gut; and respiratory system. Used to study dilated cardiomyopathy 1HH. Human ortholog(s) of this gene implicated in dilated cardiomyopathy 1HH and myofibrillar myopathy 6. Orthologous to human BAG3 (BAG cochaperone 3).
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