Go Annotations as Summary Text (Tabular View) (GO Graph)

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Automated description from the Alliance of Genome Resources (Release 7.4.0)

Enables several functions, including lipopolysaccharide binding activity; lipoteichoic acid binding activity; and peptidoglycan binding activity. Involved in several processes, including regulation of cytokine production; regulation of signal transduction; and response to bacterium. Acts upstream of with a positive effect on social behavior. Acts upstream of or within with a positive effect on defense response to Gram-negative bacterium. Acts upstream of or within with a negative effect on pyroptotic inflammatory response. Acts upstream of or within negative regulation of NLRP3 inflammasome complex assembly; phagocytosis, engulfment; and regulation of gene expression. Located in plasma membrane. Is expressed in several structures, including body wall mesenchyme; central nervous system; genitourinary system; limb interdigital region; and skin. Used to study frontotemporal dementia. Orthologous to human TREM2 (triggering receptor expressed on myeloid cells 2).

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Gene Ontology Evidence Code Abbreviations:

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