Gene Ontology Classifications

Symbol
Name
ID

Sharpin
SHANK-associated RH domain interacting protein
MGI:1913331

Go Annotations as Summary Text (Tabular View) (GO Graph)

Automated description from the Alliance of Genome Resources (Release 7.4.0)

Enables protein-macromolecule adaptor activity. Involved in negative regulation of inflammatory response; positive regulation of canonical NF-kappaB signal transduction; and regulation of tumor necrosis factor-mediated signaling pathway. Acts upstream of or within apoptotic nuclear changes; keratinization; and mitochondrion organization. Part of LUBAC complex. Is expressed in several structures, including cochlear ganglion; genitourinary system; heart; inner ear epithelium; and lung. Used to study atopic dermatitis. Orthologous to human SHARPIN (SHANK associated RH domain interactor).

Go Annotations in Tabular Form (Text View) (GO Graph)

Aspect

Category

Evidence

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

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Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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