Automated description from the Alliance of Genome Resources (Release 7.4.0)
Predicted to enable electron transfer activity; flavin adenine dinucleotide binding activity; and succinate dehydrogenase (quinone) activity. Predicted to contribute to succinate dehydrogenase activity. Predicted to be involved in mitochondrial electron transport, succinate to ubiquinone; nervous system development; and succinate metabolic process. Located in mitochondrial inner membrane and myelin sheath. Part of respiratory chain complex II (succinate dehydrogenase). Is active in mitochondrion. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and sensory organ. Human ortholog(s) of this gene implicated in Leigh disease; dilated cardiomyopathy 1GG; lung non-small cell carcinoma; mitochondrial complex II deficiency; and paraganglioma. Orthologous to human SDHA (succinate dehydrogenase complex flavoprotein subunit A).
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