Automated description from the Alliance of Genome Resources (Release 7.2.0)
Enables ubiquitin protein ligase activity. Involved in negative regulation of necroptotic process. Acts upstream of or within several processes, including positive regulation of macromolecule metabolic process; positive regulation of signal transduction; and regulation of lymphocyte proliferation. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; sensory organ; and skin. Human ortholog(s) of this gene implicated in colorectal cancer. Orthologous to human PELI1 (pellino E3 ubiquitin protein ligase 1).
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