Gene Ontology Classifications

Symbol
Name
ID

Flrt3
fibronectin leucine rich transmembrane protein 3
MGI:1918686

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Automated description from the Alliance of Genome Resources (Release 7.4.0)

Enables chemorepellent activity and fibroblast growth factor receptor binding activity. Involved in several processes, including fibroblast growth factor receptor signaling pathway; proepicardium cell migration involved in pericardium morphogenesis; and synapse organization. Acts upstream of or within positive regulation of synapse assembly. Located in several cellular components, including axonal growth cone; cell-cell junction; and extracellular space. Is active in glutamatergic synapse and postsynaptic membrane. Colocalizes with focal adhesion. Is expressed in several structures, including alimentary system; brain; embryo ectoderm; embryo mesenchyme; and eye. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 21 with or without anosmia. Orthologous to human FLRT3 (fibronectin leucine rich transmembrane protein 3).

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Aspect

Category

Evidence

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

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Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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