Go Annotations as Summary Text (Tabular View) (GO Graph)

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Automated description from the Alliance of Genome Resources (Release 7.4.0)

Enables 2',3'-cyclic GMP-AMP binding activity; cyclic-di-GMP binding activity; and ubiquitin protein ligase binding activity. Involved in several processes, including defense response to symbiont; macroautophagy; and positive regulation of innate immune response. Acts upstream of or within cellular response to interferon-beta; positive regulation of transcription by RNA polymerase II; and regulation of inflammatory response. Located in several cellular components, including Golgi membrane; autophagosome; and perinuclear region of cytoplasm. Part of STING complex. Is active in endoplasmic reticulum membrane and endoplasmic reticulum-Golgi intermediate compartment membrane. Is expressed in ductus deferens; epididymis; ileum; liver; and prostate gland. Used to study STING-associated vasculopathy with onset in infancy. Human ortholog(s) of this gene implicated in STING-associated vasculopathy with onset in infancy. Orthologous to human STING1 (stimulator of interferon response cGAMP interactor 1).

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Gene Ontology Evidence Code Abbreviations:

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