Automated description from the Alliance of Genome Resources (Release 7.2.0)
Predicted to enable phosphatidylinositol phospholipase C activity and small GTPase binding activity. Predicted to be involved in several processes, including glycerolipid metabolic process; intracellular signal transduction; and positive regulation of lamellipodium assembly. Predicted to act upstream of or within lipid catabolic process and signal transduction. Predicted to be located in cytosol; lamellipodium; and plasma membrane. Is expressed in several structures, including facial bone primordium; heart; liver; nervous system; and thymus. Human ortholog(s) of this gene implicated in gastric adenocarcinoma; nephrotic syndrome; nephrotic syndrome type 2; and nephrotic syndrome type 3. Orthologous to human PLCE1 (phospholipase C epsilon 1).
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