Go Annotations as Summary Text (Tabular View) (GO Graph)

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Automated description from the Alliance of Genome Resources (Release 7.4.0)

Predicted to enable several functions, including interleukin-1 receptor binding activity; nucleic acid binding activity; and protein homodimerization activity. Involved in several processes, including positive regulation of intestinal epithelial cell development; positive regulation of macromolecule biosynthetic process; and regulation of defense response. Acts upstream of or within several processes, including cellular response to chloroquine; negative regulation of ERK1 and ERK2 cascade; and regulation of dendritic cell cytokine production. Located in cytoplasmic vesicle; endoplasmic reticulum; and plasma membrane. Is expressed in brain and intestine. Used to study systemic lupus erythematosus. Human ortholog(s) of this gene implicated in several diseases, including allergic bronchopulmonary aspergillosis; cystic fibrosis; glomerulonephritis (multiple); hepatitis B; and lung disease (multiple). Orthologous to human TLR9 (toll like receptor 9).

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Gene Ontology Evidence Code Abbreviations:

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