Automated description from the Alliance of Genome Resources (Release 7.1.0)
Involved in several processes, including axon guidance; morphogenesis of an epithelium; and regulation of synapse pruning. Acts upstream of or within several processes, including heart morphogenesis; inner ear development; and morphogenesis of an epithelium. Located in several cellular components, including basolateral plasma membrane; lateral plasma membrane; and stress fiber. Is active in glutamatergic synapse and postsynaptic density membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system epithelium; and sensory organ. Used to study neural tube defect. Human ortholog(s) of this gene implicated in neural tube defect. Orthologous to human VANGL2 (VANGL planar cell polarity protein 2).
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