Automated description from the Alliance of Genome Resources (Release 7.2.0)
Enables several functions, including NAD-dependent histone H3K9 deacetylase activity; p53 binding activity; and transcription coregulator activity. Involved in several processes, including regulation of fat cell differentiation; regulation of gene expression; and regulation of signal transduction. Acts upstream of or within several processes, including behavioral response to starvation; cellular response to leukemia inhibitory factor; and negative regulation of macromolecule biosynthetic process. Located in mitochondrion and nucleus. Part of heterochromatin. Is expressed in several structures, including brain; gonad; heart; metanephros; and sensory organ. Used to study Alzheimer's disease; nephrogenic diabetes insipidus; and steatotic liver disease. Human ortholog(s) of this gene implicated in Huntington's disease and prostate cancer. Orthologous to human SIRT1 (sirtuin 1).
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