Go Annotations as Summary Text (Tabular View) (GO Graph)

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Automated description from the Alliance of Genome Resources (Release 7.4.0)

Predicted to enable calcium ion binding activity. Involved in post-embryonic retina morphogenesis in camera-type eye and visual perception. Acts upstream of with a positive effect on gene expression. Acts upstream of with a negative effect on protein localization. Acts upstream of or within several processes, including detection of light stimulus involved in visual perception; establishment of bipolar cell polarity involved in cell morphogenesis; and neurogenesis. Located in several cellular components, including adherens junction; microvillus; and photoreceptor outer segment. Part of subapical complex. Is active in apical part of cell. Is expressed in several structures, including alimentary system; central nervous system; epidermis; genitourinary system; and sensory organ. Used to study Leber congenital amaurosis 8 and retinitis pigmentosa 12. Human ortholog(s) of this gene implicated in pigmented paravenous chorioretinal atrophy and retinal disease (multiple). Orthologous to human CRB1 (crumbs cell polarity complex component 1).

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Gene Ontology Evidence Code Abbreviations:

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