Automated description from the Alliance of Genome Resources (Release 7.5.0)
Enables DNA helicase activity and DNA-directed DNA polymerase activity. Involved in double-strand break repair via alternative nonhomologous end joining; negative regulation of double-strand break repair via homologous recombination; and somatic hypermutation of immunoglobulin genes. Acts upstream of or within DNA repair. Predicted to be located in Golgi apparatus; cytosol; and nucleoplasm. Predicted to be active in site of double-strand break. Is expressed in embryo; heart; spleen; and testis. Orthologous to human POLQ (DNA polymerase theta).
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