Automated description from the Alliance of Genome Resources (Release 7.4.0)
Enables choline binding activity and choline transmembrane transporter activity. Involved in choline transport and transport across blood-brain barrier. Acts upstream of or within several processes, including brain development; endothelial tip cell fate specification; and in utero embryonic development. Is active in plasma membrane. Is expressed in several structures, including central nervous system and yolk sac. Used to study proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome. Human ortholog(s) of this gene implicated in proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome. Orthologous to human FLVCR2 (FLVCR choline and putative heme transporter 2).
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