Automated description from the Alliance of Genome Resources (Release 7.2.0)
Enables ubiquitin protein ligase activity. Involved in negative regulation of smoothened signaling pathway. Acts upstream of or within protein polyubiquitination. Predicted to be located in endoplasmic reticulum. Predicted to be active in early endosome; nucleus; and plasma membrane. Is expressed in several structures, including genitourinary system; heart; node; and skin. Orthologous to human MGRN1 (mahogunin ring finger 1).
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