Go Annotations as Summary Text (Tabular View) (GO Graph)

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Automated description from the Alliance of Genome Resources (Release 7.4.0)

Enables alkaline phosphatase activity; phosphoamidase activity; and pyrophosphatase activity. Involved in several processes, including futile creatine cycle; inhibition of non-skeletal tissue mineralization; and positive regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including cellular response to organic cyclic compound; endochondral ossification; and response to antibiotic. Located in extracellular matrix; extracellular membrane-bounded organelle; and plasma membrane. Is active in mitochondrial intermembrane space and mitochondrial membrane. Is expressed in several structures, including alimentary system; genitourinary system; hemolymphoid system gland; limb; and skeleton. Used to study adult hypophosphatasia; childhood hypophosphatasia; and infantile hypophosphatasia. Human ortholog(s) of this gene implicated in adult hypophosphatasia; childhood hypophosphatasia; hypophosphatasia; and infantile hypophosphatasia. Orthologous to human ALPL (alkaline phosphatase, biomineralization associated).

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Gene Ontology Evidence Code Abbreviations:

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