Go Annotations as Summary Text (Tabular View) (GO Graph)

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Automated description from the Alliance of Genome Resources (Release 7.4.0)

Predicted to enable growth factor activity; nerve growth factor receptor binding activity; and neurotrophin TRKB receptor binding activity. Involved in several processes, including negative regulation of apoptotic signaling pathway; positive regulation of neuron projection development; and trans-synaptic signaling by BDNF, modulating synaptic transmission. Acts upstream of or within several processes, including modulation of chemical synaptic transmission; neuron differentiation; and regulation of neurogenesis. Located in several cellular components, including dendrite; perinuclear region of cytoplasm; and secretory granule. Is active in glutamatergic synapse; hippocampal mossy fiber to CA3 synapse; and neuronal dense core vesicle. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in several diseases, including cocaine dependence; cognitive disorder (multiple); congenital central hypoventilation syndrome; neurodegenerative disease (multiple); and obstructive sleep apnea. Orthologous to human BDNF (brain derived neurotrophic factor).

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Gene Ontology Evidence Code Abbreviations:

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