Automated description from the Alliance of Genome Resources (Release 7.5.0)
Enables several functions, including alpha-catenin binding activity; disordered domain specific binding activity; and enzyme binding activity. Involved in several processes, including nervous system development; regulation of neurogenesis; and regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including embryonic morphogenesis; kidney development; and positive regulation of cell population proliferation. Located in several cellular components, including apicolateral plasma membrane; basolateral plasma membrane; and euchromatin. Part of several cellular components, including Scrib-APC-beta-catenin complex; Wnt signalosome; and nucleus. Is active in several cellular components, including Schaffer collateral - CA1 synapse; postsynaptic density, intracellular component; and synaptic membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Used to study autism spectrum disorder; exudative vitreoretinopathy; otitis media; reproductive organ cancer (multiple); and urinary bladder cancer. Human ortholog(s) of this gene implicated in several diseases, including autosomal dominant intellectual developmental disorder 19; exudative vitreoretinopathy 7; hepatocellular carcinoma (multiple); nephroblastoma; and pilomatrixoma. Orthologous to human CTNNB1 (catenin beta 1).
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