Automated description from the Alliance of Genome Resources (Release 7.2.0)
Predicted to enable CD40 receptor binding activity; integrin binding activity; and protein serine/threonine kinase activator activity. Involved in isotype switching. Acts upstream of or within B cell differentiation and regulation of immunoglobulin production. Located in external side of plasma membrane. Is expressed in Meckel's cartilage; dorsal root ganglion; and limb. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; artery disease (multiple); autoimmune disease (multiple); combined T cell and B cell immunodeficiency (multiple); and hematologic cancer (multiple). Orthologous to human CD40LG (CD40 ligand).
This site uses cookies.
Some cookies are essential for site operations and others help us analyze use and utility of our web site.
Please refer to our
privacy policy
for more information.