Go Annotations as Summary Text (Tabular View) (GO Graph)

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Automated description from the Alliance of Genome Resources (Release 7.4.0)

Enables bicarbonate transmembrane transporter activity and chloride channel activity. Involved in several processes, including cellular response to cAMP; chloride transmembrane transport; and positive regulation of transport. Acts upstream of or within several processes, including chloride transport; cholesterol biosynthetic process; and cholesterol transport. Located in apical plasma membrane and cytosol. Is expressed in several structures, including alimentary system; brain; genitourinary system; musculoskeletal system; and respiratory tract epithelium. Used to study cystic fibrosis. Human ortholog(s) of this gene implicated in several diseases, including alcoholic pancreatitis; allergic bronchopulmonary aspergillosis; bronchial disease (multiple); congenital bilateral absence of vas deferens (multiple); and lung disease (multiple). Orthologous to human CFTR (CF transmembrane conductance regulator).

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Gene Ontology Evidence Code Abbreviations:

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