Gene Ontology Classifications

Symbol
Name
ID

Sh2b3
SH2B adaptor protein 3
MGI:893598

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Automated description from the Alliance of Genome Resources (Release 7.5.0)

Enables protein tyrosine kinase binding activity; signaling receptor complex adaptor activity; and stem cell factor receptor binding activity. Involved in several processes, including cellular response to cytokine stimulus; megakaryocyte development; and negative regulation of signal transduction. Acts upstream of or within with a negative effect on cellular response to chemokine. Acts upstream of or within embryonic hemopoiesis; hematopoietic stem cell differentiation; and intracellular signal transduction. Predicted to be active in plasma membrane. Is expressed in aorta-gonad-mesonephros; dorsal aorta; liver; lower jaw molar; and upper jaw molar. Used to study chronic myeloid leukemia. Human ortholog(s) of this gene implicated in colorectal cancer; essential thrombocythemia; familial erythrocytosis 1; myelofibrosis; and type 1 diabetes mellitus. Orthologous to human SH2B3 (SH2B adaptor protein 3).

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Aspect

Category

Evidence

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

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Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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