Go Annotations as Summary Text (Tabular View) (GO Graph)

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Automated description from the Alliance of Genome Resources (Release 7.4.0)

Enables several functions, including DNA (cytosine-5-)-methyltransferase activity; nucleic acid binding activity; and zinc ion binding activity. Involved in DNA methylation-dependent heterochromatin formation and negative regulation of gene expression via chromosomal CpG island methylation. Acts upstream of or within with a positive effect on epigenetic programming of gene expression. Acts upstream of or within several processes, including cellular response to bisphenol A; chromosomal DNA methylation maintenance following DNA replication; and negative regulation of macromolecule biosynthetic process. Located in female germ cell nucleus; pericentric heterochromatin; and replication fork. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in Graves' disease; autosomal dominant cerebellar ataxia, deafness and narcolepsy; hereditary sensory neuropathy; hereditary sensory neuropathy type 1E; and lung non-small cell carcinoma. Orthologous to human DNMT1 (DNA methyltransferase 1).

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Gene Ontology Evidence Code Abbreviations:

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