Go Annotations as Summary Text (Tabular View) (GO Graph)

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Automated description from the Alliance of Genome Resources (Release 8.0.0)

Enables epidermal growth factor receptor binding activity; receptor ligand activity; and transmembrane receptor protein tyrosine kinase activator activity. Involved in several processes, including ERBB2-EGFR signaling pathway; negative regulation of cholesterol efflux; and positive regulation of ubiquitin-dependent protein catabolic process. Acts upstream of or within several processes, including mammary gland alveolus development; positive regulation of cell population proliferation; and positive regulation of protein tyrosine kinase activity. Located in plasma membrane. Is active in extracellular space. Is expressed in several structures, including 1st branchial arch; alimentary system; brain; exocrine system; and genitourinary system. Human ortholog(s) of this gene implicated in several diseases, including Zollinger-Ellison syndrome; hepatobiliary system cancer (multiple); high grade glioma (multiple); lung non-small cell carcinoma (multiple); and primary hypomagnesemia (multiple). Orthologous to human EGF (epidermal growth factor).

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Gene Ontology Evidence Code Abbreviations:

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