Automated description from the Alliance of Genome Resources (Release 7.5.0)
Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and enzyme binding activity. Involved in several processes, including cellular response to gamma radiation; circadian temperature homeostasis; and regulation of biosynthetic process. Acts upstream of or within several processes, including BMP signaling pathway; negative regulation of transcription by RNA polymerase II; and skeletal muscle cell differentiation. Located in nucleus. Is expressed in several structures, including brain; embryo mesenchyme; genitourinary system; jaw; and sensory organ. Used to study myelodysplastic syndrome. Human ortholog(s) of this gene implicated in asthma. Orthologous to human EGR1 (early growth response 1).
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